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Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Do not breastfeed during treatment and for 6 months after your last dose of TRUXIMA

are breastfeeding or plan to breastfeed.

Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with TRUXIMA.

Talk to your healthcare provider about effective birth control.

You should use effective birth control (contraception) during treatment with TRUXIMA and for 12 months after your last dose of TRUXIMA.

Your healthcare provider should do a pregnancy test to see if you are pregnant before starting TRUXIMA.

Talk to your healthcare provider about the risks to your unborn baby if you receive TRUXIMA during pregnancy

are pregnant or plan to become pregnant.

You should not receive certain vaccines before or during treatment with TRUXIMA

have had a recent vaccination or are scheduled to receive vaccinations.

Varicella zoster virus (chickenpox or shingles).

have or have had any severe infections including:.

have an infection or weakened immune system.

have a history of heart problems, irregular heart beat, or chest pain.

have had a severe reaction to TRUXIMA or a rituximab product.decreased strength or weakness on one side of your bodyīefore you receive TRUXIMA, tell your healthcare provider about all of your medical conditions, including if you:.Tell your healthcare provider right away if you have any new or worsening symptoms or if anyone close to you notices these symptoms: There is no known treatment, prevention, or cure for PML. PML can result in death or severe disability. People with weakened immune systems can get PML. PML is a rare, serious brain infection caused by a virus that can happen in people who receive TRUXIMA. Progressive Multifocal Leukoencephalopathy (PML).

Tell your healthcare provider right away if you get worsening tiredness, or yellowing of your skin or white part of your eyes, during treatment with TRUXIMA. Your healthcare provider will monitor you for hepatitis B infection during and for several months after you stop receiving TRUXIMA. You should not receive TRUXIMA if you have active hepatitis B liver disease. Hepatitis B reactivation may cause serious liver problems including liver failure, and death. If you have had hepatitis B or are a carrier of hepatitis B virus, receiving TRUXIMA could cause the virus to become an active infection again. Before you receive your TRUXIMA treatment, your healthcare provider will do blood tests to check for HBV infection. painful sores or ulcers on your skin, lips, or in your mouth.Tell your healthcare provider or get medical help right away if you get any of these symptoms at any time during your treatment with TRUXIMA: palpitations (feel like your heart is racing or fluttering).swelling of your lips, tongue, throat, or face.shortness of breath, difficulty breathing, or wheezing.Tell your healthcare provider or get medical help right away if you get any of these symptoms during or after an infusion of TRUXIMA: Your healthcare provider should give you medicines before your infusion of TRUXIMA to decrease your chance of having a severe infusion-related reaction. Serious infusion-related reactions can happen during your infusion or within 24 hours after your infusion of TRUXIMA. Infusion-related reactions are very common side effects of TRUXIMA treatment. TRUXIMA can cause serious side effects that can lead to death, including:

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